Insulin-like growth factor-1 induces the phosphorylation of PRAS40 via the PI3K/Akt signaling pathway in PC12 cells

► The proline-rich Akt substrate of 40 kDa (PRAS40) is a substrate of Akt. ► IGF-1 induces the phosphorylation of Akt at Thr473 and PRAS40 at Thr246 in PC12 cells. ► IGF-1 induced phosphorylation of PRAS40 is mediated by the PI3K/Akt pathway.