GABAB receptor-mediated ERK1/2 phosphorylation via a direct interaction with CaV1.3 channels

► The CaV1.2 and CaV1.3 channels are the 2 main types of neuronal L-type Ca2+ channels. ► Functions of CaV1.3 have not been well elucidated compared to CaV1.2. ► Direct involvement of CaV1.3 channels in GABAB-mediated ERK1/2 signal pathway. ► Direct involvement of CaV1.3 channels in GABAB-mediated faciltation of L-type Ca2+ channels. ► Important implications of CaV1.3/GABABR clusters for translating synaptic activity into gene expression alterations.