Prolonged nitric oxide treatment induces tau aggregation in SH-SY5Y cells

► Prolonged NO treatment recapitulates pathological alterations found in AD brain in SH-SY-5Y cells. ► Prolonged NO treatment induces soluble tau oligomers in SH-SY-5Y cells. ► Prolonged NO treatment induces insoluble tau mega-aggregates in SH-SY-5Y cells.