کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6284241 1296676 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of neuronal nitric oxide synthase in the antiallodynic effects of intrathecal EGCG in a neuropathic pain rat model
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Role of neuronal nitric oxide synthase in the antiallodynic effects of intrathecal EGCG in a neuropathic pain rat model
چکیده انگلیسی

Epigallocatechin-3-gallate (EGCG), the major catechin in green tea, is known to have antioxidant activity against nitric oxide (NO) by scavenging free radicals, chelating metal ions, and inducing endogenous antioxidant enzymes. NO and NO synthase (NOS) play an important role in nociceptive processing. In this study, we examined the effects of intrathecal EGCG in neuropathic pain induced by spinal nerve ligation and the possible involvement of NO. Intrathecal EGCG attenuated mechanical allodynia in spinal nerve ligated-rats, compared to sham-operated rats, with a maximal possible effect of 69.2%. This antinociceptive effect was reversed by intrathecal pretreatment with l-arginine, a precursor of NO. Intrathecal EGCG also blocked the increase in nNOS expression in the spinal cord of spinal nerve-ligated rats, but iNOS expression was not significantly suppressed. These findings suggest that intrathecal EGCG could produce an antiallodynic effect against spinal nerve ligation-induced neuropathic pain, mediated by blockade of nNOS protein expression and inhibition of the pronociceptive effects of NO.

► Intrathecal epigallocatechin-3-gallate (EGCG) shows antiallodynia in neuropathic pain. ► It blocks the increase of neuronal nitric oxide synthase (nNOS) in spinal cord of rat. ► Nitric oxide precursor reduces the antiallodynic effect of intrathecal EGCG. ► We suggest the antiallodynic effect of intrathecal EGCG is mediated by spinal nNOS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 510, Issue 1, 21 February 2012, Pages 53-57
نویسندگان
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