Neuroprotective effects of Kv7 channel agonist, retigabine, for cisplatin-induced peripheral neuropathy

► Threshold tracking can non-invasively provide axonal membrane properties. ► Cisplatin depolarizes the membrane potential in the peripheral nerves. ► Retigabine showed neuroprotective effects by normalizing the membrane potential. ► Kv7 channel may become a useful therapeutic target for neuroprotection.