Hypothermia enhances the colocalization of calmodulin kinase IIα with neuronal nitric oxide synthase in the hippocampus following cerebral ischemia

► We investigate the neuroprotective mechanism of hypothermia. ► Cerebral ischemia dissociates CaM-KIIα from nNOS in the CA1 hippocampus. ► Hypothermia induces the colocalization of CaM-KIIα with nNOS in CA1 hippocampus. ► CaM-KIIα attenuates the activity of nNOS. ► This effect is one of the neuroprotective mechanisms of hypothermia.