Phosphodiesterase-3B is expressed in proopiomelanocortin and neuropeptide Y neurons in the mouse hypothalamus

► PDE3B pathway plays an important role in mediating hypothalamic action of leptin. ► This study shows expression of PDE3B in POMC and NPY neurons in the hypothalamus. ► PDE3B is also expressed in the hypothalamic nuclei implicated in energy homeostasis. ► Direct PDE3B signaling appears to mediate leptin action in POMC and NPY neurons.