The effect of a monoclonal antibody to calcitonin-gene related peptide (CGRP) on injury-induced ectopic discharge following lingual nerve injury

► Previously we showed that CGRP can increase ectopic discharge at nerve injury sites. ► Here we monitor the effect of anti-CGRP antibody on injured nerve fibre activity. ► Systemic anti-CGRP does not modify activity in injured lingual nerve fibres. ► Activity in injured lingual nerve fibres is not affected by sequestration of CGRP. ► Other modulators may offer better therapeutic targets for nerve injury-induced pain.