Stressful environmental and social stimulation in adolescence causes antidepressant-like effects associated with epigenetic induction of the hippocampal BDNF and mossy fibre sprouting in the novelty-seeking phenotype

► ESS exposure during adolescence results in antidepressant-like effect in HRs. ► ESS exposure during adolescence results in epigenetic induction of BDNF in HRs. ► ESS exposure during adolescence results in mossy fibre sprouting in HRs. ► ESS exposure during adolescence may constitute environmental therapy in HRs.