Sex differences in the effects of perinatal anoxia on dopamine function in rats

► We examined sex differences in the long-term effects of perinatal anoxia. ► Anoxia produced sex-dependent effects on sensorimotor gating (males most impaired). ► Apomorphine-induced suppression of PPI was stronger in males than females. ► Dopamine systems in PFC and n. accumbens were also altered sex-dependently. ► Dopamine in amygdala was altered by anoxia similarly in males and females.