Membrane resonance and its ionic mechanisms in rat subthalamic nucleus neurons

► Little is known about mechanisms of oscillatory activity in STN in now day. ► We studied the resonance characteristics of STN neurons using patch-clamp. ► There is a θ-frequency resonance mediated by Ih current in individual STN neurons. ► The resonance of STN neurons is temperature- and voltage-dependent. ► The resonance mediates a coupling between inputs and firing.