کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6284638 | 1296699 | 2011 | 6 صفحه PDF | دانلود رایگان |
Endothelin-1 (ET-1) is one of potential factors to induce vasogenic edema formation, since exogenous ET-1 treatment decreases aquaporin 4 (AQP4) expression and increases chemokines induction. To identify the role of endogenous ET-1 in vasogenic edema formation, we examined the correlation between endogenous ET-1 expression and vasogenic edema formation in the pirifom cortex following status epilepticus (SE). In the present study, SMI-71 (a brain-blood barrier marker) immunoreactivity was significantly reduced in blood vessels at 1 day after SE when vasogenic edema and neuronal damage were observed. ET-1 expression was up-regulated in endothelial cells prior to reduction in SMI-71 immunoreactivity. Furthermore, ET-1 expressing endothelial cells showed the absence of SMI-71 immunoreactivity. Increase in ET-1 expression was followed by reduced AQP4 immunoreactivity prior to vasogenic edema formation. Only a few microglia showed monocyte chemotactic protein-1 (a chemokine induced by ET-1) outside vasogenic edema lesion. Taken together, our findings suggest that endothelial ET-1 expression may contribute to SE-induced vasogenic edema formation via brain-blood barrier disruption at AQP4/MCP-1 independent manners.
- ET-1 was observed in PC neurons in Non-SE animals.
- ET-1 expressing endothelial cells showed the absence of SMI-71 immunoreactivity following SE.
- Increase in ET-1 expression was followed by reduced AQP4 immunoreactivity.
- ET-1 expression was no correlated to MCP-1 expression.
- ET-1 may contribute to SE-induced vasogenic edema at AQP4/MCP-1 independent manners.
Journal: Neuroscience Letters - Volume 501, Issue 1, 21 August 2011, Pages 25-30