Amphetamine sensitization in reproductively experienced female rats

► Effects of reproductive experience on amphetamine sensitization were tested. ► Primiparous and nulliparous female rats were treated with 0, 1, or 5 mg/kg amphetamine for 5 days. ► Animals were treated with amphetamine (1 or 5 mg/kg) or saline for 5 consecutive days. ► All animals were challenged with low-dose amphetamine after 10 days of withdrawal. ► High-dose amphetamine treatment increased response to challenge in primiparous rats. ► Increased amphetamine sensitization may be a consequence of reproductive experience.