Induction of pluripotent stem cells from autopsy donor-derived somatic cells

► Human iPSCs provide an avenue for investigating neurological disease mechanisms. ► Many neurodegenerative diseases are commonly misdiagnosed in live patients. ► Postmortem histopathological review of a donor brain increases diagnostic accuracy. ► Postmortem cells can be made into iPSCs that are capable of neural differentiation. ► Postmortem fibroblast proliferation is effected by biopsy site but not donor age.