Olanzapine plus fluoxetine treatment increases Nt-3 protein levels in the rat prefrontal cortex

► Treatment with fluoxetine and olanzapine alone or in combination did not alter BDNF or NGF protein levels. ► Treatment with fluoxetine (25 mg/kg) and olanzapine (6 mg/kg) in combination increased NT-3 protein levels. ► NT-3 could be involved in the effect of treatment with antipsychotic and antidepressant combination in mood disorders.