Lauroylethanolamide and linoleoylethanolamide improve functional outcome in a rodent model for stroke

► Previously uncharacterized N-acylethanolamines effective in rat model for stroke. ► Linoleoylethanolamide reduces lesion size after middle cerebral artery occlusion. ► Lauroylethanolamide and linoleoylethanolamide improve functional outcome after stroke. ► N-acylethanolamines are promising neuroprotectants for stroke therapy.