Encapsulated native and glucagon-like peptide-1 transfected human mesenchymal stem cells in a transgenic mouse model of Alzheimer's disease

► Cerebral transplantation of mesenchymal stem cell (MSC) in mice model of Alzheimers disease. ► Comparison of encapsulated native and glucagon-like peptide-1 (GLP-1) transfected MSC. ► Decreased amyloid depositions with native MSC. ► Supression of plaque associated glial and microglial response with GLP-1 transfected MSC. ► Encapsulation of MSC may alter biological activity of MSC.