Simultaneous conditioning of “gaping” responses and taste avoidance in rats injected with LiCl and saccharin: Examining the role of context and taste cues in the rodent model of anticipatory nausea

► Systemic LiCl in novel environment conditions anticipatory nausea. ► Systemic saccharin treatment is effective CS in taste avoidance conditioning. ► LiCl + Saccharin condition high gaping frequencies and low saccharin preference. ► Rats can simultaneously associate internal/external conditioning cues with LiCl US. ► Present simultaneous conditioning model of anticipatory nausea and taste avoidance.