A Caenorhabditis elegans p38 MAP kinase pathway mutant protects from dopamine, methamphetamine, and MDMA toxicity

► We examine the effects of methamphetamine and MDMA on Caenorhabditis elegans. ► A p38 MAP kinase pathway mutant provides resistance to methamphetamine and MDMA toxicity. ► Innate immunity may protect against pathologic processes involving biogenic amines.