Effects of intragastric injection of glutamate on efferent sympathetic nerve activity in rats

► A present study examined effects of MSG on sympathetic nerve tones. ► Intragastric MSG increased renal and WAT sympathetic nerve activities in fasted-rats. ► Effects of MSG on sympathetic excitation was suppressed in vagotomized rats. ► We concluded the afferent pathway may be involved in the sympathetic activation of WAT and kidneys.