The protective roles of mitochondrial ATP-sensitive potassium channels during hypoxia-ischemia-reperfusion in brain

▶ Activation of mitoKATP channels can protect neurons against injury and death. ▶ The neuroprotection of diazoxide is better than pinacidil. ▶ KATP openers may mainly effect on Kir6.1mRNA to induce protective role. ▶ Diazoxide may become a new treatment for cerebral ischemia diseases.