Tau-tubulin kinase-1 gene variants are associated with Alzheimer's disease in Han Chinese

▶ The rs2651206 polymorphism of TTBK1 is associated with LOAD. ▶ The minor allele of rs2651206 is a protective factor for LOAD. ▶ The minor alleles of rs2651206 and rs7764257 define a protective haplotype. ▶ TTBK1 gene variants are associated with LOAD in Han Chinese.