Oral methylphenidate establishes a conditioned place preference in rats

▶ There are no preclinical data on the abuse liability of oral methylphenidate (MPH). ▶ This study compared doses of oral and i.p. MPH on conditioned place preference (CPP). ▶ Each route of MPH established CPP. ▶ Higher doses of oral MPH are needed to establish CPP. ▶ This model can be used to study factors needed for oral MPH CPP.