Effects of polyinosinic-polycytidylic acid (Poly I:C) on naloxone-precipitated withdrawal in morphine-dependent mice

▶ Poly I:C is used to trigger immune challenge in mice. ▶ Naloxone is used to introduce withdrawal in morphine-dependent mice. ▶ Poly I:C has no effects on acute physical withdrawal symptoms. ▶ Poly I:C enhances depressive-like behavior in a tail suspension test. ▶ Immune challenge may contribute addiction relapse.