Nicotine enhances contextual fear memory reconsolidation in rats

▶ Nicotine immediately after reactivation enhances contextual fear response. ▶ Nicotine 6 h after reactivation does not affect contextual fear response. ▶ The enhanced effect of nicotine is memory reactivation-dependent. ▶ Nicotine does not affect nonspecific freezing response 24 h after injection.