Adenosine A1 receptors in human brain and transfected CHO cells: Inhibition of [3H]CPFPX binding by adenosine and caffeine

▶ Adenosine and caffeine displace [3H]CPFPX from human brain A1 adenosine receptors. ▶ IC50 of adenosine for CPFPX is reached during conditions like hypoxia. ▶ IC50 of caffeine for CPFPX is reached by commonly consumed amounts of caffeine.