Involvement of dorsal hippocampal α1-adrenergic receptors in the effect of WIN55,212-2 on memory retrieval in inhibitory avoidance task

▶ Post-training or pre-test intra-CA1 administration of WIN55,212-2 impairs memory. ▶ WIN55,212-2 induces a state-dependent learning. ▶ Pre-test intra-CA1 injection of phenylephrine restores WIN55,212-2 amnesia. ▶ Pre-test intra-CA1 injection of prazosin inhibited WIN55,212-2 state-dependent learning.