Chronic cerebral hypoperfusion in a mouse model of Alzheimer's disease: An additional contributing factor of cognitive impairment

▶ A mixed dementia model was induced by occlusion of right CCA in Tg2576 mice. ▶ Chronic cerebral hypoperfusion aggravates cognitive deficits of Tg2576 mice. ▶ Decreased metabolic rate shown on the microPET in mice with operation.