Testing the silence of mutations: Transcriptomic and behavioral studies of GABAA receptor α1 and α2 subunit knock-in mice

▶ Ethanol-resistant mutations (H270, A277) in the α1 subunit of the GABAA-R. ▶ Changes in brain gene expression, including the γ2 subunit of GABAA-R. ▶ Modified responses to drugs selective for γ-containing GABAA-R in α1 knockin mice. ▶ This was not seen in α2 knockin mice.