Chronic l-tyrosine alters the locomotor activity and brain monoamine levels in Roborovskii hamsters

▶ The Roborovskii hamster has high locomotor activity and low DA levels. ▶ Chronic supplementation of l-tyrosine decreased locomotor activity. ▶ Tyrosine increased DA and NE turnover rates and decreased in 5-HT turnover rate. ▶ Long-term feeding of l-tyrosine may be effective for high locomotor activity.