Detection of acid-sensing ion channel 3 (ASIC3) in periodontal Ruffini endings of mouse incisors

▶ mRNA for ASIC1, 2, 3 in rat trigeminal ganglion neurons.▶ ASIC3 immunoreaction in medium-sized neurons which mediate mechanotransduction. ▶ Axonal branches of the periodontal Ruffini endings positive for ASIC3. ▶ No ASIC3 reaction in free nerve endings. ▶ ASIC3 functioning as a molecule for mechanosensation.