Kv7 (KCNQ) channel openers induce hypothermia in the mouse

▶ Kv7 channel openers induce hypothermia with a rapid onset of action. ▶ The hypothermic effect of Kv7 channel openers is Kv7 channel-specific ▶ Modulation of GABAergic activity may contribute to the hypothermic effect ▶ Kv7 channel-induced hypothermia may be associated with the anxiolytic effects ▶ The hypothermic effect may be a confounding factor in behavioral settings.