کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6285567 1296840 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cilostazol protects against hemorrhagic transformation in mice transient focal cerebral ischemia-induced brain damage
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Cilostazol protects against hemorrhagic transformation in mice transient focal cerebral ischemia-induced brain damage
چکیده انگلیسی

Cilostazol, an antiplatelet drug used to treat intermittent claudication, has been reported to offer neuroprotection and endothelial protection in animals with ischemic brain injury. Here, we evaluated the protection afforded by cilostazol against ischemic brain injury and hemorrhagic transformation. Mice subjected to a 2-h filamental middle cerebral artery (MCA) occlusion were treated with cilostazol (10 mg/kg, intraperitoneally just after the occlusion) or with vehicle. Histological outcomes (infarct volume and hemorrhagic transformation) and Evans blue extravasation were assessed after reperfusion. Mean infarct volume, hemorrhagic transformation, and Evans blue extravasation were all significantly reduced in the cilostazol-treated group. Thus, cilostazol protected against ischemic brain injury and hemorrhagic transformation in mice subjected to transient focal cerebral ischemia.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 452, Issue 2, 13 March 2009, Pages 156-161
نویسندگان
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