کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6285623 | 1296855 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Histamine excites rat lateral vestibular nuclear neurons through activation of post-synaptic H2 receptors
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Through whole-cell patch recordings in brainstem slices, the effects of histamine on neuronal activity of the lateral vestibular nucleus (LVN) were investigated. Bath application of histamine elicited a concentration-dependent excitation of both spontaneous firing (n = 19) and silent (n = 7) LVN neurons. Moreover, histamine induced a stable inward current in the LVN neurons (n = 5) and the histamine-induced depolarization of membrane potential persisted in the presence of tetrodotoxin (n = 4), indicating a direct post-synaptic effect of the histamine on the LVN neurons. Selective histamine H2 receptor antagonist ranitidine effectively blocked the histamine-evoked excitatory responses on the LVN neurons (n = 4), but selective histamine H1 receptor antagonist triprolidine did not (n = 4). In addition, selective histamine H2 receptor agonist dimaprit (n = 3) rather than 2-pyridylethylamine (n = 4), a selective histamine H1 receptor agonist, mimicked the excitatory action of histamine on LVN neurons. The results demonstrate that histamine excites the LVN neurons via post-synaptic histamine H2 receptors and suggest that the central histaminergic projection arising from the hypothalamus may modulate LVN neurons activity and actively influence the vestibular reflexes and functions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 448, Issue 1, 19 December 2008, Pages 15-19
Journal: Neuroscience Letters - Volume 448, Issue 1, 19 December 2008, Pages 15-19
نویسندگان
Jun Zhang, Xiao-Hu Han, Hong-Zhao Li, Jing-Ning Zhu, Jian-Jun Wang,