کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6285751 | 1296863 | 2008 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
TNF-alpha polymorphisms are associated with obsessive-compulsive disorder
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Introduction: Several lines of evidence support an immunologic involvement in obsessive-compulsive disorder (OCD): the increased prevalence of OCD in patients with rheumatic fever (RF), and the aggregation of obsessive-compulsive spectrum disorders among relatives of RF probands. Tumor necrosis factor alpha is a proinflammatory cytokine involved in RF and other autoimmune diseases. Polymorphisms in the promoter region of the TNFA gene have been associated with RF. Given the association between OCD and RF, the goal of the present study was to investigate a possible association between polymorphisms within the promoter region of TNFA and OCD. Materials and methods: Two polymorphisms were investigated: â308 G/A and â238 G/A. The allelic and genotypic frequencies of these polymorphisms were examined in 111 patients who fulfilled DSM-IV criteria for OCD and compared with the frequencies in 250 controls. Results: Significant associations were observed between both polymorphisms and OCD. For â238 G/A, an association between the A allele and OCD was observed (Ï2 = 12.05, p = 0.0005). A significant association was also observed between the A allele of the â308 G/A polymorphism and OCD (Ï2 = 7.09, p = 0.007). Finally, a haplotype consisting of genotypes of these two markers was also examined. Significant association was observed for the A-A haplotype (p = 0.0099 after correcting for multiple testing). Discussion: There is association between the â308 G/A and â238 G/A TNFA polymorphisms and OCD in our Brazilian sample. However, these results need to be replicated in larger samples collected from different populations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 442, Issue 2, 12 September 2008, Pages 86-90
Journal: Neuroscience Letters - Volume 442, Issue 2, 12 September 2008, Pages 86-90
نویسندگان
Ana Gabriela Hounie, Carolina Cappi, Quirino Cordeiro, Aline Santos Sampaio, Ivanil Moraes, Maria Conceição do Rosário, Selma A. Palácios, Anna Carla Goldberg, Homero Pinto Vallada, Ariane Machado-Lima, Eduardo Nakano, Jorge Kalil, David Pauls,