کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6285909 | 1296960 | 2007 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Induction of IP-10 (CXCL10) in astrocytes following Japanese encephalitis
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Chemokines and their receptors are important elements for the selective attraction and activation of various subsets of leukocytes. Interferon-gamma inducible protein (IP-10 or CXCL-10) is a potent chemoattractant and has been suggested to enhance the severity of virus infection and neuronal injury. In order to assess functional importance of this chemokine in viral encephalitis, we have exploited an experimental model of Japanese encephalitis. We report for the first time that in Japanese encephalitis, astrocytes are the predominant source of IP-10. A progressive increase in IP-10 induction following viral infection is concomitant with the increase in IFN-γ a known inducer of IP-10. However, this increase in IFN-γ level is not sufficient to confer protection as animals eventually succumb to the infection.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 414, Issue 1, 27 February 2007, Pages 45-50
Journal: Neuroscience Letters - Volume 414, Issue 1, 27 February 2007, Pages 45-50
نویسندگان
Sourojit Bhowmick, Rachna Duseja, Sulagna Das, Mohan Babu Appaiahgiri, Sudhanshu Vrati, Anirban Basu,