کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6286043 | 1615282 | 2015 | 4 صفحه PDF | دانلود رایگان |
- Oxytocin is an important synaptic modulator in the posterodorsal medial amygdala.
- Oxytocin can modulate the number of differently shaped spines.
- Oxytocin plays a crucial role in the regulation of female mice reproduction.
The posterodorsal medial amygdala (MePD) is a sexually dimorphic area in the social behavior neural network, with high concentration of oxytocin (OT) receptors. Wild type (WT) and OT knockout (OTKO) females were studied in proestrus, and Golgi-impregnated spines in the MePD were classified. Results show that the OTKO group has increased density of thin, mushroom, and stubby/wide spines when compared to the WT (p < 0.01 in all cases). These data indicate that OT is an important synaptic modulator in the MePD, a finding that is likely involved with the display of the female sexual behavior.
Journal: Neuroscience Research - Volume 101, December 2015, Pages 53-56