Connexin43 mimetic peptide is neuroprotective and improves function following spinal cord injury

► We tested if connexin43 modulation was protective in spinal cord injury. ► We examined changes in behaviour, neuroinflammation and neuronal survival. ► Treatment with mimetic peptide led to an improvement in locomotion. ► Treatment led to a reduction in the degree of neuroinflammation ► Treatment led to improved neuronal survival.