کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6286449 1298106 2011 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rapid communicationNociceptive cortical responses during capsaicin-induced tactile allodynia in mice with spinal dorsal column lesioning
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Rapid communicationNociceptive cortical responses during capsaicin-induced tactile allodynia in mice with spinal dorsal column lesioning
چکیده انگلیسی

We investigated nociceptive cortical responses using transcranial flavoprotein fluorescence imaging in anesthetized mice with capsaicin-induced allodynia. Tactile stimuli applied to the hindpaw produced fluorescence increases in the contralateral somatosensory cortex of naïve mice. Lesioning of the ipsilateral dorsal column in the spinal cord abolished most of the cortical responses. However, the responses to the same tactile stimuli appeared again after capsaicin was injected into the hindpaw. The capsaicin treatment reduced the thresholds of the hindpaw withdrawal responses. These findings strongly suggest that the responses to tactile stimuli in the lesioned mice after capsaicin injection represented nociceptive cortical responses.

Research highlights▶ Cortical responses were recorded in mice with capsaicin-induced allodynia. ▶ Tactile cortical responses were abolished by spinal dorsal column lesioning. ▶ Cortical responses appeared again after hypodermic capsaicin injection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 69, Issue 4, April 2011, Pages 348-351
نویسندگان
, , , , ,