Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases

► Palmitoylation is a protein lipid modification regulating localization and function. ► Six palmitoyl acyltransferases (PATs) are implicated in neuropsychiatric diseases. ► HIP14 and HIP14L are unique PATs with ankyrin repeat domains. ► Dysfunctional HIP14 may contribute to Huntington disease.