کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6287137 1615568 2016 26 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Assessment of thermal treatment via irrigation of external ear to reduce cisplatin-induced hearing loss
ترجمه فارسی عنوان
ارزیابی درمان حرارتی از طریق آبیاری گوش خارجی به منظور کاهش ضربان قلب ناشی از سیس پلاتین
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی سیستم های حسی
چکیده انگلیسی
Systemic and local changes in body temperature can have a profound effect on traumatic injuries including those to the inner ear. Therefore, we investigated the effects of acutely increasing or decreasing the temperature of the external ear canal on cisplatin-induced hearing loss. The external auditory canals of male guinea pigs were acutely irrigated with warm (44 °C), euthermic (37 °C), or cool (30 °C) water and subsequently injected with cisplatin (12 mg/kg, i.p.). Hearing was assessed by the auditory brainstem response and cochleograms were prepared to determine loss of hair cells. Ear canal irrigation with warm water potentiated cisplatin-induced hearing loss and outer hair cell loss whereas cool ear canal irrigation showed significant protection from cisplatin-induced hearing loss and outer hair cell loss. These results suggest that non-invasive cool water ear canal irrigation may be highly effective clinical procedure for protecting against cisplatin-induced hearing loss.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 332, February 2016, Pages 55-60
نویسندگان
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