کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6287137 | 1615568 | 2016 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Assessment of thermal treatment via irrigation of external ear to reduce cisplatin-induced hearing loss
ترجمه فارسی عنوان
ارزیابی درمان حرارتی از طریق آبیاری گوش خارجی به منظور کاهش ضربان قلب ناشی از سیس پلاتین
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کلمات کلیدی
سیس پلاتین، اتوکسیکسیت، حرارتی حفاظت هیپوترمی، هیپرترمی،
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های حسی
چکیده انگلیسی
Systemic and local changes in body temperature can have a profound effect on traumatic injuries including those to the inner ear. Therefore, we investigated the effects of acutely increasing or decreasing the temperature of the external ear canal on cisplatin-induced hearing loss. The external auditory canals of male guinea pigs were acutely irrigated with warm (44 °C), euthermic (37 °C), or cool (30 °C) water and subsequently injected with cisplatin (12 mg/kg, i.p.). Hearing was assessed by the auditory brainstem response and cochleograms were prepared to determine loss of hair cells. Ear canal irrigation with warm water potentiated cisplatin-induced hearing loss and outer hair cell loss whereas cool ear canal irrigation showed significant protection from cisplatin-induced hearing loss and outer hair cell loss. These results suggest that non-invasive cool water ear canal irrigation may be highly effective clinical procedure for protecting against cisplatin-induced hearing loss.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 332, February 2016, Pages 55-60
Journal: Hearing Research - Volume 332, February 2016, Pages 55-60
نویسندگان
Christopher Spankovich, Edward Lobarinas, Dalian Ding, Richard Salvi, Colleen G. Le Prell,