کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6287422 | 1615584 | 2014 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Factors associated with hearing loss in a normal-hearing guinea pig model of hybrid cochlear implants
ترجمه فارسی عنوان
عوامل مرتبط با کاهش شنوایی در مدل قارچ جراحی طبیعی از ایمپلنت های کیسه ای هیبریدی
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کلمات کلیدی
CISCAESOHCSGNABREASCASACEeABR - EABRHearing loss - از دست دادن شنواییIHC - ایمونوهیستوشیمیouter hair cell - سلول بیرونی موInner hair cell - سلول داخلی داخلیhair cell - سلول موHearing aid - سمعکIntramuscular - عضلانیspiral ganglion neuron - نورون گانگلیون مارپیچیauditory brainstem response - پاسخ شنوایی مغزElectrically-evoked auditory brainstem response - پاسخ مغزی شنوایی شنوایی الکتریکیCochlear implant - کاشت حلزونی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
سیستم های حسی
چکیده انگلیسی
After surgery, implanted animals experienced a range of 0-55Â dB of threshold shifts in the vicinity of the electrode at 6 and 16Â kHz. The degree of hearing loss was significantly correlated with reduced stria vascularis vessel density and with the presence of ossification, but not with hair cell counts, spiral ganglion neuron density, or fibrosis area. After 10 weeks of stimulation, 67% of implanted, stimulated animals had more than 10Â dB of additional threshold shift at 1Â kHz, compared to 17% of implanted, non-stimulated animals and 0% of non-implanted animals. This 1-kHz hearing loss was not associated with changes in any of the cochlear measures quantified in this study. The variation in hearing loss after surgery and electrical stimulation in this animal model is consistent with the variation in human patients. Further, these findings illustrate an advantage of a normal-hearing animal model for quantification of hearing loss and damage to cochlear structures without the confounding effects of chemical- or noise-induced hearing loss. Finally, this study is the first to suggest a role of the stria vascularis and damage to the lateral wall in implantation-induced hearing loss. Further work is needed to determine the mechanisms of implantation- and electrical-stimulation-induced hearing loss.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Hearing Research - Volume 316, October 2014, Pages 82-93
Journal: Hearing Research - Volume 316, October 2014, Pages 82-93
نویسندگان
Chiemi Tanaka, Anh Nguyen-Huynh, Katherine Loera, Gemaine Stark, Lina Reiss,