Protection by low-dose kanamycin against noise-induced hearing loss in mice: Dependence on dosing regimen and genetic background

► CBA/J mice are protected from cochlear noise injury by low-dose kanamycin. ► Protection requires only a few doses spaced no more than 48 h apart. ► Protection is not dependent on age, at least up to 1 yr. ► Protection is associated with significant preservation of outer hair cells. ► Dosing regimens that work well in CBA/J mice are ineffective in C57BL/6J mice.