Expression and secretion of Aspergillus fumigatus proteases are regulated in response to different protein substrates

► Aspergillus fumigatus produces allergens with protease activity. ► Growth on protein based substrates induces the secretion of proteases. ► Mainly serine proteases secreted in response pig lung homogenate or mucin media. ► Predominately MMP secreted in response to casein media. ► Aspergillus fumigatus can sense and respond to changes in growth environment.