Natural products as inhibitors of recombinant cathepsin L of Leishmania mexicana

- Natural products were screened against L. mexicana cathepsin L (rCPB2.8).
- A triterpene and some flavonoids are inhibitors of rCPB2.8.
- The inhibitors of rCPB2.8 are partially noncompetitive and uncompetitive.
- The mechanism would be an advantage in the search for selective inhibitors.