Research BriefEffects of albendazole nanoparticles in mice with hepatic echinococosis: Portal vein cannulation versus intravenous administration

- ABZ may have systemic drug toxicity.
- Portal vein cannulation was used to deliver the antiparasitic agent.
- The portal vein cannulation group had high concentration of ABZ-SO in blood samples.
- The portal vein cannulation group had high concentration of ABZ-SO in cyst samples.

To compare the ABZ and its metabolites concentration in cyst tissue of hepatic alveolar echinococcosis administered by different routes, forty male Wistar rats receiving albendazole nanoparticles from tail vein and portal vein were divided into two groups, the concentration of ABZ and its metabolites ABZSO, ABZSO2, in the cyst tissue, were analyzed by HPLC at 2, 4, 8, 24, 36 h after administration. The parent drug and its metabolites were detected in plasm and the cyst tissue after portal cannulation and intravenous administration. The last results were the concentration of ABZ in the portal cannulation group was higher than in the intravenous group at every time point (p < 0.05). Compared to the intravenous group, the portal cannulation administration of ABZ led to a lower plasm concentration of ABZ. The concentration of ABZ and the active ABZSO were significantly higher in the portal cannulation group than that of the intravenous group.

Graphical Abstract