Investigation of infectivity of neonates and adults from different rat strains to Toxoplasma gondii Prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection

- Different strains of rat show variation in resistance to T. gondii infection.
- The balance of iNOS/Arginase-1 activity of host is strongly linked to resistance.
- The rat is a good model for understanding toxoplasmosis in humans.
- Neonates of rat already show similar resistance to Toxoplasma infection as adults.