Trypanocidal action of tea tree oil (Melaleuca alternifolia) against Trypanosoma evansi in vitro and in vivo used mice as experimental model

- Trypanosoma evansi is the etiologic agent of trypanosomosis.
- The parasite has been recorded several cases of resistance to antiprotozoal.
- Tea tree oil (TTO) and tea tree oil nanocapsules (TTO nanocapsules) have trypanocidal action in vitro.
- Animals that received TTO and TTO nanocapsules have extended longevity in mice.
- Association of TTO and diminazene aceturate potentiates the curative effect to T. evansi in mice.