The endogenous cytokine profile and nerve fibre density in mouse ear Leishmania major-induced lesions related to nociceptive thresholds

► Fibres density decrease with the hyperalgesia in Leishmania major infected C57BL/6 mice. ► The pro-inflammatory cytokines upregulate during hyperalgesia in C57BL/6. ► The anti-inflammatory cytokines downregulate during hypoalgesia in BALB/c. ► Cytokines, innervation and tissue damage are correlated in leishmaniasis.