Gnathostoma spinigerum: Immunodepression in experimental infected mice

► G. spinigerum infected mice spleen cell was tested for lymphoproliferative responses. ► Significant depression to Con A and specific antigen stimulations were observed. ► This immunodepression was depended on the chronicity and dose of infection. ► T cell response is defective but could be reversible by anthelminthic treatment. ► The involvement of Th-2 response in regulating T cell proliferation was suggested.